Dengue Disease

  • A serious viral disease in the tropic and subtropic areas of the world
  • One of the most rapidly spreading mosquito borne diseases
  • Dengue virus (DENV) is an enveloped virus and a member of Flaviviridae family with four distinct serotypes : DENV-1,DENV-2,DENV-3 and DENV-4
  • Can manifests fatally into dengue hemorrhagic fever and dengue shock syndrome
  • Severity of the disease is linked to number of viruses in the blood during viremic stage
  • Currently no specific anti-dengue medication and treatment procedure is merely supportive. No approved dengue vaccine available.
  • Hence desired to find therapeutic remedy to reduce the virus count in addition to inhibit virus replication in cells

Dengue cases and death in Malaysia

  • According to the Health Ministry, 336 people died from dengue in 2015 compared to 215 in 2014.
  • A rise of 56% and was the highest number of dengue deaths ever recorded in the country.
  • An increase of some 11.2% of dengue cases, up from 108,698 in 2014 to 120,836 cases in 2015.
  • A total of 2,404 dengue cases have been recorded nationwide for a mere 5 days period from Jan 3 to Jan 7, 2016
  • Equivalent to an average of 480 cases per day!


Photo credit: Oregon State University via Visual hunt / CC BY-SA

 

Dengue Cases in Malaysia from 1995-2017

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Modeling Occurrence of Dengue Cases in Malaysia

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Article from WHO on Dengue situation as of 12 September 2019

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